Pest Management Regulatory Agency
4 October 2024
The Pest Management Regulatory Agency (PMRA) is modernizing its pesticide review process through the implementation of a continuous oversight model. As part of this process modernization effort, the PMRA’s approach for verifying product chemistry information of technical grade active ingredient products is updated.
Verifying product chemistry as part of continuous oversight is an important component for ensuring that health and environmental risk assessments are relying on the best available chemistry information. This initiative will contribute to improved monitoring of pesticide active ingredients to confirm they are being manufactured consistent with approved specifications and methods. It will also ensure that the PMRA’s chemistry review is up-to-date when an active undergoes re-evaluation, resulting in more timely decisions.
To provide registrants with advance notice of when their active ingredients will be subject to chemistry verification and to keep other interested stakeholders informed, the PMRA is maintaining a transparent five-year chemistry verification work plan, which will be updated annually. Footnote 1
Through this updated process, chemistry verification for each active ingredient is expected to occur at least every 10 years, with the flexibility to require chemistry verification sooner when warranted. For example:
When actives or sources are known to contain impurities or contaminants of health or environmental concern;
When the PMRA becomes aware of a potential issue that requires further assessment;
When there is a history of discrepancies in specifications for certain actives or sources.
Registrants will be requested to submit listed chemistry information regarding their active ingredient, including quality control data, description of the current manufacturing process and up-to-date product specification form. When needed, the PMRA will request additional GLP-compliant chemistry batch data and/or impurity of concern data to support continued registration.
If the chemistry verification determines that the product composition is not within approved specifications, or the manufacturing process has changed without proper reporting, Health Canada may consider appropriate compliance and enforcement actions.
Additional details on the process are provided in the “Memorandum to Registrants: Verifying Chemistry of Registered Technical Grade Active Ingredients and Integrated System Products”.
Below is the five-year chemistry verification work plan for 1 April 2024 to 31 March 2029.
Active ingredients subject to chemistry verification in 2024-2025
Acibenzolar-s-methyl
3-(Trimethoxysilyl)propyldimethyloctadecyl ammonium chloride
3-(Trihydroxysilyl)propyldimethyloctadecyl ammonium chloride
Butoxypolypropylene glycol
Citric acid
Castor oil
Dichlorprop-p (present as dimethylamine salt)
Dichlorprop-p
Dichlorprop p-isomer (present as 2-ethylhexyl ester)
1,4-Dimethylnaphthalene
Diodofon
Diquat
Dried eggs
Fish meal mixture
Fish oil mixture
Flonicamid
Garlic oil
Garlic powder
Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine
Imazethapyr
3-Iodo-2-propynyl butyl carbamate
Iron (present as FeHEDTA)
d-Limonene
Meat meal mixture
Mesosulfuron-methyl
Metconazole
Metrafenone
Naphthalene
Oxalic acid dihydrate
Paradichlorobenzene
Saponins of Chenopodium quinoa (food grade)
Sodium fluoride
Tefluthrin
Tembotrione
Thiabendazole
Thymol
Tralkoxydim
Wintergreen oil
Gibberellic acid
Gibberellins A4 and A7 Footnote 2
Calcium hypochlorite Footnote 2
Putrescent whole egg solids Footnote 2
Sodium chloride
Sodium hypochlorite Footnote 2
Active ingredients subject to chemistry verification in 2025-2026
1,2-Benzisothiazolin-3-one, BIT
6-Benzylaminopurine (or: 6-benzyladenine)
Bromoxynil
Chloridazon
2,4-D
2,4-D (present as amine salts: dimethylamine salt, diethanolamine salt, or other amine salts)
2,4-D (present as low volatile esters)
2,4-D (present as choline salt)
Dicamba (present as acid, ester, salt)
Dodine
Ethametsulfuron-methyl
Imazapyr
Mandipropamid
MCPA (present as acid)
MCPA (present as amine salts: diethanolamine, dimethylamine, or mixed amines)
MCPA (present as esters)
MCPA (present as potassium salt or as sodium salt)
Mineral oil
Nicosulfuron
Oxirane derivatives (50% minimum)
Pendimethalin
2-Phenylphenol
2-Phenylphenol (present as potassium salt)
2-Phenylphenol (present as sodium salt)
Propylene glycol
Rimsulfuron
Sodium chlorate
Sodium chlorite
Spirotetramat
Sulfentrazone
Tetrakis (hydroxymethyl) phosphonium sulfate (THPS)
Active ingredients subject to chemistry verification in 2026-2027
n-Alkyl(25% c12, 60% c14, 15% c16)dimethylbenzylammonium chloride
Alkyl(40% c12, 50% c14, 10% c16)dimethylbenzylammonium chloride
n-Alkyl(68% c12, 32% c14)dimethyl ethylbenzyl ammonium chloride
n-Alkyl (60% c14, 30% c16, 5% c12, 5% c18)dimethyl benzyl ammonium chloride
n-Alkyl(40% c12, 50% c14, 10% c16)dimethylbenzylammonium saccharinate
n-Alkyl(67% c12, 25% c14, 7% c16, 1% c18)dimethylbenzylammonium chloride
Diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride
n-Dialkyl(5% c12, 60% c14, 30% c16, 5% c18)methylbenzylammonium chloride
1-Alkyl(c6-c18)-1,3-propanediamine
N-Alkyl-1,3-propanediamine acetate
N-coco-alkyl trimethylene diamines (present as monobenzoate salt)
1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin, hydroxymethyl-5,5-dimethylhydantoin
Ammonium soap of fatty acid
Bifenthrin
Carbathiin
Chlorthal (present as dimethyl ester)
Cloransulam-methyl
Chlormequat chloride
Codlelure
Cyprosulfamide
n-Decanol
Desmedipham
Diazinon
Didecyldimethylammonium chloride
Dimethenamid-p
Dioctyldimethylammonium chloride
Dithiopyr
Flumioxazin
Formetanate hydrochloride
Glutaraldehyde
Hexazinone
Imazamethabenz-methyl
Lime sulphur
Mono- and dipotassium phosphite
Metsulfuron-methyl
Metaldehyde
Maleic hydrazide
Naphthylacetic acid
Oxydiethylene bis(alkyl dimethyl ammonium chloride)
1-Octanol
r-(-)-1-Octen-3-ol
Octyldecyldimethylammonium chloride
Oxycarboxin
Ozone
Picloram (present as acid)
Picloram (present as amine salts)
Picloram (present as potassium salt)
Propyzamide
Phenmedipham
Saflufenacil
Simazine plus related active triazines
Streptomycin
Thiencarbazone-methyl
Thifensulfuron-methyl
Tribenuron-methyl
Trifluralin
Available chlorine, present as sodium hypochlorite Footnote 3
Active ingredients subject to chemistry verification in 2027-2028
Ancymidol
Arsenic acid
Available chlorine present as 1-bromo-3-chloro-5,5-dimethylhydantoin and related hydantoins
Available bromine present as 1-bromo-3-chloro-5,5-dimethylhydantoin and related hydantoins
Available chlorine present as 1-bromo-3-chloro-5,5-dimethylhydantoin, 1,3-dichloro-5,5-dimethylhydantoin, 1,3-dichloro-5-ethyl-5-methylhydantoin and related hydantoins
Available chlorine present as 1,3-dichloro-5,5-dimethylhydantoin and 1,3- dichloro-5-ethyl-5-methylhydantoin
Clopyralid (present as acid, or as salts)
Copper (present as copper naphthenate)
Copper (present as copper 8-quinolinolate)
Copper, present as basic copper carbonate
Basic copper sulfate
Bromethalin
Chlorpropham
Chlorsulfuron
Chromic acid
Citronella oil
Clomazoneb
Copper (present as cuprous oxide, cupric oxide and metallic copper)
Copper (present as cupric oxide)
Creosote
Cyazofamid
Diflubenzuron
Diphacinone (present in free form or as sodium salt)
Diphenylamine
Dried blood
Endothal or endothall
EPTC
Fluopicolide
Formaldehyde
Formic acid
Icaridin
Indaziflam
3-Methyl-2-cyclohexen-1-one
Methyl nonyl ketone
Metofluthrin
Oriental mustard seed meal
Paraformaldehyde
Penflufen
Penthiopyrad
Propiconazole
Verbenone
Extract of Reynoutria sachalinensis
Zinc as elemental (present as zinc naphthenate)
Zinc (present as zinc oxide)
Available chlorine, present as calcium hypochlorite Footnote 4
Active ingredients subject to chemistry verification in 2028-2029
Abamectin
Acequinocyl
Ametoctradin
Aminopyralid
Ammonia (present as ammonium sulfate)
Ammonium bromide
Atrazine (plus related active triazines)
Azoxystrobin
Bifenazate
Bensulide
Benzyl benzoate
Bromacil (present in free form, as dimethylamine salt, or as lithium salt)
Liquid carbon dioxide
Cloquintocet-mexyl
Chlorfenapyr
Cyantraniliprole
Denatonium benzoate
3-Decen-2-one
1,2-Dibromo-2,4-dicyanobutane
Difethialone
Dodecylguanidine hydrochloride
Ethalfluralin
(E,Z)-2,13-octadecadien-1-yl acetate
Fenoxaprop-p-ethyl
Ferric sodium ethylenediaminetetraacetic acid
Fluazifop-p-butyl and s-isomer
Fluopyram
Fluoxastrobin
Fluxapyroxad
Fosetyl-al
Garlic juice
Glufosinate-ammonium
Halosulfuron (present as methyl ester)
Hydramethylnon
Imiprothrin
Kasugamycin hydrochloride hydrate
Malathion
MCPB
MCPB (present as sodium salt)
Mesotrione
Metalaxyl-m and S-isomer
1-Methylcyclopropene
Metribuzin
Mono- and dibasic sodium, potassium, and ammonium phosphites
Myclobutanil
Naled
Natamycin
Niclosamide
Octenol
Oil of lemon eucalyptus, hydrated, cyclized
d-Phenothrin
Potassium dimethyldithiocarbamate
Poly[oxyethylene(dimethyliminio)ethylene(dimethyliminio)ethylene dichloride]
Picoxystrobin
Pyroxasulfone
Quinclorac (present as dimethylamine salt)
Sedaxane
S-metolachlor and R-enantiomer
Sulfoxaflor
Tea tree oil
Tetraconazole
Tributyl tetradecyl phosphonium chloride
Footnotes
Footnote 1
This five-year work plan may change in response to workload and emerging issues that require priority action.
Return to footnote 1 referrer
Footnote 2
Only select sources for these active ingredients will be subject to chemistry verification in fiscal year 2024-25
Return to footnote 2 referrer
Footnote 3
Only select sources for this active ingredient will be subject to chemistry verification in fiscal year 2026-27
Return to footnote 3 referrer
Footnote 4
Only select sources for this active ingredient will be subject to chemistry verification in fiscal year 2027-28
Return to footnote 4 referrer
